Dr. Etienne L. Sibille is Chair of the Campbell Family Mental Health Research Institute and Senior Scientist at the Centre for Addiction and Mental Health. He is also a Professor in the Department of Psychiatry and the Department of Pharmacology and Toxicology at the University of Toronto.
Dr. Sibille’s research goals have consistently focused on translational research aimed at identifying the cellular and molecular bases of depression, specifically of the mood, affect and cognitive components of the illness. His laboratory studies encompass parallel investigations in postmortem brains of depressed and control subjects, and in preclinical genetic and environmental models, with the aims of characterizing the primary pathology of depression and assessing causal links between identified molecular changes or candidate neurotransmitter systems and mood regulation. Current projects include translating human postmortem findings on the role of the GABA microcircuitry in mood regulation, and specifically of reduced somatostatin-positive dendritic targeting interneuron function.